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Supplements, devices, lifestyle programs and longevity drugs, each graded A to D on what trials in people found. Medications checked for what they can lower and what they interact with.
For you and your family: plain answers first. Where to begin → For clinicians: the full evidence trail. For clinicians →
Or start from your goal: Heart and blood vessels Brain and mood Blood sugar Bones Strength and falls Sleep Hearing and vision Living longer
No more guessing.
What the letters mean
Each grade is for one use, not the bottle.
Grade A: Replicated
Replicated trials on a qualifying endpoint
Trials in people found a real benefit on an outcome that counts, and separate research groups found it again.
Grade B: Supported
A good trial, backed by more
A good trial in people found a benefit, and other studies back it up.
Grade C: Limited
Small, mixed or unreplicated trials
The trials are small, mixed, or not yet repeated. Too soon to be sure.
Grade D: Not shown
No human trial shows benefit
Either no one has tested it in people, or the trials found no benefit or found harm.
A D is never one bucket. We say which:
526 graded uses. Most land at C.
What you get
One person's list, checked. Medications are checked, not graded, so they get no letter. Open a row to see why.
What one person takes
In plain wordsCan lower your vitamin B12 and folate. Possibly CoQ10, not proven.
EvidenceMedications are checked, not graded, so there is no letter. Evidence tier on each depletion A fall in a nutrient's level caused by a medication, for example through reduced absorption or increased loss. record: vitamin B12, well documented; folate, well documented; CoQ10, possible, not proven.
In plain wordsIn care homes, vitamin D taken with calcium meant fewer broken bones. Alone, it did not.
EvidenceGrade B. Measured on a hard clinical endpoint An outcome that matters directly to a person and is counted without judgment, such as death, heart attack, stroke or fracture.. 4 PubMed-indexed papers on this use. Replicated benefit on hip fracture in older adults living in institutions. Not A: the large community trials did not reproduce it.
Caution on the recordHypercalcemia Too much calcium in the blood. Mild cases cause few symptoms; higher levels can bring thirst, confusion, kidney stones and heart rhythm problems. from any cause. Sarcoidosis, tuberculosis and other granulomatous disease A disease in which the immune system walls off irritation in small clusters of inflamed cells called granulomas, as in sarcoidosis and tuberculosis. These clusters can activate vitamin D on their own., where extrarenal Outside the kidneys. The kidneys normally control how much vitamin D is turned into its active form; activation elsewhere in the body escapes that control. conversion can produce hypercalcemia at ordinary doses. Primary hyperparathyroidism. Sustained intake above 10,000 IU/day without monitoring.
In plain wordsLarge trials found it did not prevent cancer. In one, it raised prostate cancer in healthy men.
EvidenceGrade D, Route 2 Human randomized trials have been run and did not show benefit on the stated outcome. One of the two routes to the lowest letter on EBL's scale.: TESTED, HARM FOUND. Measured on a hard clinical endpoint. 8 PubMed-indexed papers on the record. Every large randomized trial of vitamin E for cancer prevention found no benefit. In SELECT, 400 IU a day of synthetic vitamin E increased prostate cancer in healthy men.
Caution on the recordAnyone already at raised bleeding risk. Separation from surgery is the usual clinical margin.
Scale A · B · C · DOpen a row to see why
Each grade is for one use, not the bottle.
Your own list
It stays on this device. Nothing you type is sent anywhere.
The check is step 1 of 6. See the full method →
One supplement, two grades
With resistance training, in adults over 65.
Two independent research groups found bigger strength gains than placebo An inactive substitute made to look like the real treatment, so participants cannot tell which one they received. plus the same training.
It measures strength, not falls, fractures or survival.
Women after menopause, in two-year trials.
Bone density did not improve.
The letter grades the evidence for what was tested. See the creatine page →
What moves the needle
What did the trial actually change? A letter earned on heart attacks or fractures is a different kind of evidence from a letter earned on a blood test.
Deaths and disease events
Heart attacks, strokes, fractures, cancers, deaths. Things that happen to people and are counted.
61 graded uses measured here.
What people can do or feel
Strength, fitness, alertness, sleep. Measured with a test, or reported by the person.
168 graded uses measured here.
A test number only
A blood test or other measurement moved. Whether people lived longer or better was not measured.
137 graded uses rest on a marker alone.
Each figure answers a different question, about a different outcome, group of people, comparison and length of time. The numbers cannot be compared with each other.
How a grade is made
Only studies in people count toward a letter. Animal and test-tube studies do not.
The dose, who was studied, and whether people's health changed or only a lab number did.
Every letter opens its trials, so you can see exactly why it was given.
Why you can trust it
Last grade change: October 2026 Fasting-mimicking diet: B narrowed to blood pressure; HbA1c A blood test that reflects average blood sugar over the previous two to three months. and IGF-1 graded C. 103 grade changes logged, each with its reason. See every change →
One letter that moved down
CoQ10 for chronic heart failure: A to B
The A rested on one trial that no independent group has repeated.
September 2026 · Every change, dated
One editor: Arnold Sandlow, D.C., California-licensed, Diplomate of the American Board of Anti-Aging Health Practitioners (A4M), former Founding Full Professor of Anti-Aging Studies, and author of the chapter “Enhancing Adrenal Function” in the textbook Pain Management, 6th edition. One published standard. About the editor →
Source Check · A claim that circulates, and the study behind it
The claim, as circulated
“High-protein diets shorten lifespan”
What we found: source reversed.
EBL shows you what the evidence says. It does not tell you what to take, and it does not replace your doctor.
In large randomized trials, beta-carotene supplements were tested for cancer prevention. What happened to the smokers who took them?
C) More lung cancers
In the ATBC trial, beta-carotene alone raised lung cancer in male smokers. In the CARET trial, beta-carotene with retinyl palmitate raised both lung cancer and deaths in smokers and asbestos workers, and the trial was stopped early. In mostly non-smoking groups it did nothing either way.
On EBL, Beta-Carotene (supplemental) is Grade D.
Build e404c85, November 2026